Vol. 2, Issue 1, Part A (2025)

Sneha Kalpanā, a specialized Ayurvedic pharmaceutical process involving lipid-based formulations, has gained renewed interest in the context of modern drug delivery mechanisms. Traditionally used for potentiating the therapeutic efficacy of herbs through ghee and oil media, this technique is now being evaluated for its potential role in targeted drug delivery, given the compatibility of lipids with cellular membranes and their capacity to traverse biological barriers. This paper reviews the classical understanding of Sneha Kalpanā, analyzes its pharmacokinetic implications, and critically explores how this ancient method aligns with the principles of targeted drug delivery in modern pharmacology. Key formulations such as Brahmi Ghṛita, Ashwagandhādi Taila and others are discussed with emphasis on their bioavailability, lipophilicity, and therapeutic selectivity. The review also highlights the need for advanced interdisciplinary research to validate Sneha-based carriers for site-specific drug delivery.