Vol. 2, Issue 1, Part A (2025)

Rasāyana therapy, a cornerstone of Ayurvedic rejuvenation and health-promoting practices, is deeply rooted in the pharmacological profiling of medicinal substances based on Rasa (taste), Guṇa (qualities), Vīrya (potency), and Vipāka (post-digestive effect). Among these, Rasa, Guṇa, and Vipāka play pivotal roles in determining the action and suitability of Rasāyana dravyas for long-term wellness, tissue nourishment, and disease prevention. This paper critically appraises prominent Rasāyana herbs by evaluating their classical attributes and correlating them with their pharmacodynamic actions. Through a comparative analysis of Ayurvedic theory and modern pharmacology, the study seeks to clarify how Rasa, Guṇa and Vipāka contribute to the biopotency and systemic effects of these rejuvenating agents. Emphasis is placed on herbs such as Amalaki, Guduchi, Ashwagandha, and Shatavari, while highlighting the implications of their post-digestive transformation and long-term tissue action in promoting ojas, immunity, and cellular regeneration.