Vol. 2, Issue 1, Part A (2025)

The timing of drug administration Aushadha Sevana Kāla is a critical yet often underexplored dimension of Ayurvedic pharmacotherapy. Unlike modern medicine, which predominantly focuses on dosage and formulation, Ayurveda emphasizes the role of Kāla (time) in modulating the efficacy and action (karma) of drugs. Grounded in the principles of Tridoṣa, Agni, Prakṛti, and Rogabala, Aushadha Sevana Kāla provides a dynamic framework to personalize and optimize treatment outcomes. This paper aims to conduct an analytical review of this concept by examining textual references from Bṛhat Trayī and Laghutrayī, interpreting their implications through the lens of modern chronotherapy, and correlating with available clinical and pharmacological evidence.

Shlokas from Caraka Saṁhitā, Suśruta Saṁhitā, and Aṣṭāṅga Hṛdaya are cited to build classical authority, and contemporary data is presented through figures and tables to establish evidence-based relevance. Clinical observations indicate that Ayurvedic drugs administered at dosha-specific times yield better symptom relief, digestibility, and patient compliance. The integration of Aushadha Kāla into standard clinical protocols can revolutionize the individualized approach to Ayurvedic medicine and even influence allopathic time-based therapies. The research further highlights the need to establish pharmacokinetic models for Ayurvedic drugs based on diurnal doshic fluctuations.