Vol. 2, Issue 2, Part A (2025)

Cissus quadrangularis Linn., commonly known as Asthishrinkhala or Hadjod, is a succulent vine belonging to the Vitaceae family, widely distributed in India. Traditional Ayurvedic texts credit it with bone-healing, anti-inflammatory and wound-repairing properties. Modern research has identified diverse bioactive constituents—including triterpenoids, flavonoids, stilbenes and minerals—that underpin osteogenic, antioxidant and antimicrobial activities. Clinical and preclinical studies suggest that C. quadrangularis accelerates fracture healing and may benefit bone-loss conditions. Pharmacognostical characterisation (morphology, microscopy, powder analysis) provides firm means to authenticate the drug and prevent adulteration. This review synthesises botanical taxonomy, morphological features, phytochemistry, pharmacology and standardisation efforts of C. quadrangularis, highlighting its therapeutic potential and the imperative for quality control in herbal commerce.