Vol. 3, Issue 1, Part A (2026)

Herbal drug development has evolved significantly from the ancient use of traditional plant-based medicines to the modern, scientifically validated pharmaceutical formulations. The growing interest in herbal drugs is largely attributed to their therapeutic potential, safety, and minimal side effects compared to synthetic drugs. Traditional knowledge, passed down through generations, forms the foundation for the discovery of active compounds in plants. However, the challenge remains in bridging the gap between traditional knowledge and modern scientific methods. The development of herbal drugs involves identifying bioactive compounds, conducting preclinical and clinical trials, and standardizing the formulations to ensure efficacy and safety. Regulatory frameworks, quality control measures, and the validation of therapeutic claims through evidence-based research are critical to the commercialization of herbal drugs. Furthermore, modern technologies like high-performance liquid chromatography (HPLC), mass spectrometry, and bioinformatics play an instrumental role in the isolation and analysis of active compounds from medicinal plants. This article explores the journey of herbal drug development from the traditional knowledge systems to contemporary applications in the pharmaceutical industry. We analyze the critical factors involved in the process, including the role of ethnobotany, scientific validation, and regulatory compliance. The article also discusses the challenges and opportunities in the commercialization of herbal products and their integration into mainstream medicine. It concludes by emphasizing the importance of collaborative efforts between traditional healers and modern scientists to promote the safe and effective use of herbal medicines worldwide.