Vol. 3, Issue 1, Part A (2026)

Ayurvedic medicine, an ancient system of healing, utilizes a wide variety of plant-based and mineral formulations for the treatment of various ailments. However, concerns regarding the toxicity and safety profile of these drugs have emerged with their increasing use in modern times. The present review aims to assess the toxicological aspects of Ayurvedic drugs, with a focus on identifying potential adverse effects, toxicity mechanisms, and safety considerations. Ayurvedic formulations are often composed of multiple ingredients, which may interact synergistically or antagonistically, raising concerns about their safety, especially when used in combination with other drugs or in patients with pre-existing conditions. The review evaluates existing literature on acute and chronic toxicities, including hepatotoxicity, nephrotoxicity, and genotoxicity, associated with Ayurvedic medicines. Furthermore, the review explores the role of standardization, quality control measures, and the importance of pharmacovigilance in ensuring the safety of Ayurvedic drugs. Toxicity data from animal studies, clinical trials, and case reports are reviewed to provide a comprehensive overview of the safety profile of Ayurvedic formulations. In conclusion, the review emphasizes the need for further research on the toxicology of Ayurvedic drugs, particularly in light of their widespread use in modern therapeutics, to ensure their safe and effective application in clinical practice.